Introduction: The central-governor model explains the mechanism of endurance exerciseinduced central fatigue, but high-intensity exercise-induced central fatigue has not been investigated yet. This study aimed to research how central fatigue during high-intensity intermittent pedaling alters the neural response, which results in Electroencephalography (EEG) recordings. Methods: We assessed neural response by measuring the alternation of brainwave spectral power during an intermittent high-intensity 60-minute exercise on an ergometer cycle. The cadences were changed every 10 minutes according to intermittent pattern altering (90-120-60-120-60-90 rpm). EEG was used to analyze altering brain function. Heart Rate (HR), Blood Lactate (BL), and Rating of Perceived Exertion (RPE) were measured after the change in cadences. Results: HR, BL, and RPE increased at a cadence of 120 rpm compared with 60 rpm on the ergometer cycle. The spectral power of EEG, according to cadence × brainwaves, significantly increased (P˂ 0. 01) in the alpha and beta frequency ranges with a change in cadences between 60 rpm and 120 rpm. The spectral power of the EEG significantly increased (P˂ 0. 01) over the whole frequency range from rest to warming (theta: 251%, alpha: 165%, beta: 145%) and significantly reduced in theta, alpha, and beta (theta: 176%, alpha: 142%, beta: 77%) (P≤ 0. 01). Conclusion: High-intensity exercises (90 and 120 cadences) increased brain function, regardless of fatigue occurrence. High-intensity interval training (HIIT) led to altering the neural response. It would be required to investigate the usefulness of HIIT to treat some of the psychotic disorders.

Introduction: The studies of the last two decades have shown that regular training has an important role in inhibiting breast cancer progression, alsoErbB3 function as a Therapeutic factor for reduction of tumor growth, so the aim of the study was to evaluate the comparison of High Intensity Interval Training Versus Continuous Training on the expression of ErbB3 in breast cancer bearing mice.Methods: For this purpose, 18 BALB/c mice (6-8 weeks, weight 19 ± 1.05 g), after induction of cancer (MC4-L2 subcutaneous injection into the right side of the mice), were randomly divided into three 6-member groups: high-intensity interval training, continuous training and control. Each session of high-intensity interval training group program includes sixintervals of three minutes and 20 seconds with an intensity of 85 to 90 percent of VO2max and 1 minute recovery with 30 to 35 percent VO2max intensity between each interval and The continuous training program was defined as running at 60% VO2max for 60 minutes in each session; Training programs were conducted five days a week for 10 weeks.Results: The statistical results showed thatthe expression level of ErbB3 decreased significantly in both exercise groups compared to the Control group (p=0.005); however, there was no difference between both exercise groups (p=0.304) and alsoboth continuous and interval training were effective to inhibit the growth of breast tumors, but HIT program appears to confer greater inhibitor than the continuous training program.Conclusion: It seems that HIT is more effective at inhibit breast tumor than the continuous training program.